全文获取类型
收费全文 | 3184篇 |
免费 | 132篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 37篇 |
儿科学 | 92篇 |
妇产科学 | 62篇 |
基础医学 | 456篇 |
口腔科学 | 12篇 |
临床医学 | 254篇 |
内科学 | 880篇 |
皮肤病学 | 40篇 |
神经病学 | 300篇 |
特种医学 | 55篇 |
外科学 | 370篇 |
综合类 | 32篇 |
一般理论 | 1篇 |
预防医学 | 194篇 |
眼科学 | 58篇 |
药学 | 170篇 |
中国医学 | 4篇 |
肿瘤学 | 310篇 |
出版年
2023年 | 16篇 |
2021年 | 43篇 |
2020年 | 51篇 |
2019年 | 52篇 |
2018年 | 66篇 |
2017年 | 45篇 |
2016年 | 51篇 |
2015年 | 56篇 |
2014年 | 59篇 |
2013年 | 116篇 |
2012年 | 197篇 |
2011年 | 219篇 |
2010年 | 118篇 |
2009年 | 97篇 |
2008年 | 200篇 |
2007年 | 242篇 |
2006年 | 222篇 |
2005年 | 186篇 |
2004年 | 146篇 |
2003年 | 176篇 |
2002年 | 135篇 |
2001年 | 57篇 |
2000年 | 48篇 |
1999年 | 34篇 |
1998年 | 29篇 |
1997年 | 24篇 |
1996年 | 15篇 |
1995年 | 23篇 |
1994年 | 11篇 |
1993年 | 22篇 |
1992年 | 35篇 |
1991年 | 34篇 |
1990年 | 30篇 |
1989年 | 32篇 |
1988年 | 30篇 |
1987年 | 34篇 |
1986年 | 31篇 |
1985年 | 36篇 |
1984年 | 21篇 |
1983年 | 29篇 |
1982年 | 22篇 |
1981年 | 9篇 |
1980年 | 10篇 |
1979年 | 21篇 |
1978年 | 16篇 |
1977年 | 12篇 |
1976年 | 9篇 |
1974年 | 13篇 |
1972年 | 10篇 |
1968年 | 10篇 |
排序方式: 共有3327条查询结果,搜索用时 15 毫秒
21.
Laurent Ramont Henri Thoannes Ariel Volondat Fran?ois Chastang Marie-Christine Millet Fran?ois-Xavier Maquart 《Clinical chemistry and laboratory medicine》2005,43(11):1215-1217
The concentration of neuron-specific enolase (NSE) in serum and cerebrospinal fluid (CSF) has been used as a biomarker in some cancers and, more recently, in neurodegenerative diseases. Pre-analytical conditions are very important for the quality of returned results. In this study, we evaluated the effects of storage conditions (temperature and duration of storage) and hemolysis on the concentration of NSE in serum and CSF. Our results demonstrate that samples for NSE measurement may be stored at -80 degrees C for no more than 6 months in the case of CSF and 9 months in the case of serum samples. Even invisible hemolysis may increase NSE levels in samples. Consequently, an index of hemolysis should be determined before deciding whether or not to perform NSE measurement. 相似文献
22.
Cefotaxime at a dosage of 3 gm intravenously every eight hours was administered to 80 patients with hematological malignancies and suspected septicemia. Blood samples for culturing were taken before and during antibiotic therapy. Nineteen patients had verified bacteremia and ten of them responded completely to cefotaxime. Twelve of the 19 patients had granulocyte counts of less than 0.5 X 10(9)/L. Minimal inhibitory concentrations of cefotaxime, ceftazidime, moxalactam, cefsulodin, cefoxitin, cefuroxime, and cefamandole against the pathogens were measured: cefotaxime was the best cephalosporin against gram-negative isolates and was found acceptable against gram-positive bacteria. In 61 patients no bacteremia could be demonstrated, but specific pathogens were isolated in 11 patients: from the urine in five, from the sputum in five, and from a perianal abscess in one. Complete response was obtained with cefotaxime in seven of these 11 patients. Monotherapy with cefotaxime in septicemic patients with hematological malignancies appears to be a valuable alternative to other antibiotic regimens. 相似文献
23.
Ma Qing Michael Wöltje Kathrin Schumacher Magdalena Sokalska Jaime F Vazquez-Jimenez Ralf Minkenberg Marie-Christine Seghaye 《Critical care (London, England)》2006,10(2):R57-9
Introduction
The use of moderate hypothermia during experimental cardiac surgery is associated with decreased expression of tumour necrosis factor (TNF)-α in myocardium and with myocardial protection. In order to identify the cellular mechanisms that lead to that repression, we investigated the effect of hypothermia during cardiac surgery on both main signalling pathways involved in systemic inflammation, namely the nuclear factor-κB (NF-κB) and activating protein-1 pathways. 相似文献24.
25.
Experimental autoimmune encephalomyelitis (EAE) is an animal model of demyelinating autoimmune disease, such as multiple sclerosis (MS), which is characterized by central nervous system white matter lesions, microglial activation, and peripheral T‐cell infiltration secondary to blood–brain barrier disruption. We have previously shown that treatment with tuftsin, a tetrapeptide generated from IgG proteolysis, dramatically improves disease symptoms in EAE. Here, we report that microglial expression of Neuropilin‐1 (Nrp1) is required for tuftsin‐driven amelioration of EAE symptoms. Nrp1 ablation in microglia blocks microglial signaling and polarization to the anti‐inflammatory M2 phenotype, and ablation in either the microglia or immunosuppressive regulatory T cells (Tregs) reduces extended functional contacts between them and Treg activation, implicating a role for microglia in the activation process, and more generally, how immune surveillance is conducted in the CNS. Taken together, our findings delineate the mechanistic action of tuftsin as a candidate therapeutic against immune‐mediated demyelinating lesions. GLIA 2016;64:923–936 相似文献
26.
27.
28.
29.